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Chromatography membranes use the combination of ion exchange chemistry with the high flow and processing simplicity of pre-packaged capsules. The upper surface area and large pore sizes provide high dynamic binding capacities, especially for large molecules and particles, and are easily incorporated into a process for the removal of impurities or for the purification of select molecules (coagulation factors) or viral vectors (AAV, Lentivirus). The range of scalable formats available allows them to be used in a variety of purification processes, from laboratory to manufacturing scale. The advantages offered by the membrane chromatography include, high binding efficiency due to direct access to the binding groups, even at high flow rates, lower cost of operation and vast scalability and flexibility.
COVID-19 scenario analysis:
Pharmaceutical and biotech companies came together governments around the globe are working to address the COVID-19 outbreak, from supporting the R&D of vaccines to planning for medicines supply chain challenges. The research to the development of about 115 vaccine candidates and 155 molecules are in the R&D pipeline. The commonly used drug Hydroxychloroquine is seen to be experiencing high demand. This high demand for these drugs has presented huge opportunity for manufacturers of COVID-19 management drugs, as many developed countries are having lesser resources of these drugs. The increase in demand for vaccine and treatment drugs for COVID-19, the pharmaceutical and biotechnology industry is expected to witness a lucrative growth in the future.
The major factor affecting the industry includes, rising biopharmaceutical R&D which would help the membrane chromatography market grow in the forecast period. The surge in regulatory scrutiny on the cleaning validation techniques of the downstream purification processes is also anticipated to help the market boost in the coming years. The benefits offered by the advanced membrane chromatography methods is expected to fulfill the demand posed by the membrane chromatography market would propel the industry grow. Moreover, the lack of skilled professionals for the job is expected to impede the industry growth in the near future.
In June 2017, Sartorius Stedim Biotech (SSB) expanded its range of single-use membrane chromatography solutions with Sartobind Cassettes. This convenient, pod-like modular system has been developed for commercial applications in both capture and polishing.
In January 2015, 3M Purification’s new purification technology platform, under the 3M Emphaze brand, was launched, which is designed to help biopharmaceutical manufacturers achieve high product purity early in the manufacturing process, improving efficiency and process economics. The new 3M Emphaze AEX Hybrid Purifier, the first in a series of single-use chromatographic products, uniquely combines three 3M core technologies, advanced polymer materials, fine fiber nonwovens, and porous membranes, into a novel purification media.
In March 2020, Danaher Corporation announced the completion of its acquisition of the Biopharma business from General Electric Company's Life Sciences division. Furthermore, as part of Danaher, the business will be called Cytiva and will be a standalone operating company within Danaher's Life Sciences segment.
In October 2019, Sartorius, which is a leading partner to the biopharmaceutical industry and laboratories, had signed an agreement to acquire parts of Danaher’s Life Science portfolio for approximately $750 million in cash. The businesses had combined sales turnover of approximately $140 million in 2018 with a strong growth profile and double-digit profit margins. They employ around 300 people worldwide. The proposed transaction is expected to be completed in the first quarter of 2020 and is subject to customary closing conditions and the successful acquisition of the GE Biopharma business by Danaher.
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