Int'l : +1-503-894-6022 | Toll Free : +1-800-792-5285 | help@alliedmarketresearch.com
A08293 | Pages: NA | Charts: NA | Tables: NA |
Animal models continue to be important tools to understand disease mechanisms and for preclinical testing of potential therapeutics. As a model of human disease, rat offers many advantages over mouse and other organisms. In fact, rats were the most widely used organisms in medical research, and the successful isolation of rat ES (embryo-derived stem) cells is expected to quickly expand their utility. Rat is preferred over other animal models as its size enhances its use as a disease model. It is not only due to its ability to perform surgical procedures but also due to its proportional size of important substructures in organs that affects both how much of the organ is involved in an experimental lesion and the effects of drug administration to specific anatomical areas. This is particularly important in the central nervous system. In addition, the studies of cognition and memory have shown that the rat is superior to other models due to the physiological systems involved in learning; hence, its memory has been extensively studied. Rat is more intelligent than mouse and is capable of learning a wider variety of tasks that are important to cognitive research. Furthermore, rat is the primary model for mechanistic studies of human reproduction and has become a standardized physiological and toxicological model, particularly in the pharmaceutical industry.
COVID-19 scenario analysis:
Rats were the first mammalian species specifically domesticated to be used in the laboratory. Two centuries ago, the brown rat Rattus norvegicus was used by scientists to understand human physiology and medicine, concentrating on the effects of food and oxygen deprivation. With advancements, rats were used in various therapeutic areas. Rats are an ideal choice for human disease research due to their physiological similarity to humans. With the sequencing of rat genome, it is now know that almost all disease-linked human genes have counterparts in rats. In addition, with the advancement in gene editing and gene targeting, it is possible to specifically modify the rat genome. This helps to enhance the understanding of human disease and its treatment with the help of different rat models. Furthermore, rise in incidence of chronic disease, introduction of new infectious strains, need for advanced treatment or vaccines against new infectious microorganisms, and continuous investments & grants are the major growth drivers of the rat model market.
A new rat model of Angelman syndrome (AS) involves complete deletion of the maternal UBE3A gene, which causes multiple behavioral and neurological abnormalities. This model could be useful for better understanding AS and for testing new therapies. The new study describes a model of AS generated by deleting the full maternal UBE3A gene in rats. In addition, a rat model of AS offers advantages over a mouse model as rat’s social behavior is somewhat more “human-like” than mouse behavior. The model was generated using a CRISPR-Cas9 gene-editing system, which allows genes to be cut at any desired location, a tailor-made genetic modification. The ZDSD rat colony was started by crossing ZDF/GMI rats with Crl: CD rats in 2001 at PreClinOmics under the direction of Dr. Richard Peterson. They continued the inbreeding of the ZDSD rat colony until generation 57 (2018) in the PreClinOmics breeding facilities and was given to Charles River in 2018 from CrownBio. Furthermore, ZDSD rat is ideally used to study type 2 diabetes, pre-diabetes, obesity, metabolic syndrome (insulin resistance, dyslipidemia, and hypertension), and diabetic complications (nephropathy, neuropathy, fatty liver). With the advancement in technology, new rat strains are becoming trends and fostering the growth of the rat model market.
Key benefits of the report:
Questions answered in the rat model market research report:
Key Market Segments
Key Market Players
