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2023

Bone Grafts And Substitutes Market

Bone Grafts and Substitutes Market Size, Share, Competitive Landscape and Trend Analysis Report by Type (Allografts, Bone grafts substitutes, Cell based matrices), by Application (Spinal fusion, Trauma, Joint reconstruction, Dental bone grafting, Craniomaxillofacial), by End user (Hospitals, Specialty clinics, Others): Global Opportunity Analysis and Industry Forecast, 2021-2031

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Author's: Shraddha Mali | Roshan Deshmukh
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Bone Grafts And Substitutes Market Research, 2031

The global bone grafts and substitutes market size was valued at $2,586.30 million in 2021, and is projected to reach $4,005.26 million by 2031, growing at a CAGR of 4.5% from 2022 to 2031. Bone grafts and substitutes refer to materials that are used to replace or stimulate the growth of bone tissue. They are often used in orthopedic procedures to repair or replace damaged or diseased bone tissue, such as in the case of bone fractures, spinal injuries, or bone cancer. Bone grafts and substitutes can be used in a variety of forms, such as powders, granules, pastes, or putties. They are designed to provide a scaffold for new bone tissue to grow around, promoting bone healing and regeneration. The patient's age, the size and location of the bone deficiency, also the surgeon's preference will all affect the choice of bone graft and substitute material to be used.

Bone Grafts and Substitutes Market

Market Dynamics

Growth & innovations in the orthopedic sector for the manufacturing of advanced bone grafts, creates an opportunity for the bone grafts and substitutes market. Rise in product approvals of various bone grafts, and increase in investments by various key players across the globe are set to affect the market growth positively. In addition, rise in prevalence of orthopedic disorders and increase in number of surgeries are expected to drive the growth of the market. For instance, an article of the National Health Service 2022 reported that 70,000 knee replacement surgeries are carried out every year. In addition, rise in geriatric population is expected to drive the bone grafts and substitutes market opportunity, owing to rise in incidences of arthritic conditions in aged population.

The growth of the bone grafts and substitutes market is expected to be driven by emerging markets, due to the availability of improved healthcare infrastructure, increase in unmet healthcare needs, rise in prevalence of spinal disorders, and surge in demand for bone grafting procedures. Furthermore, the healthcare industry in emerging economies is developing at a significant rate, owing to rise in demand for enhanced healthcare services, significant investments by government to improve healthcare infrastructure, and development of the medical tourism industry in emerging countries. The demand for bone grafts and substitutes is not only limited to developed countries but is also being witnessed in the developing countries, such as China, Brazil, and India, which fuel the growth of the market. In addition, the prevalence of bone disorders such as osteoporosis, bone cancer, and spinal deformities is increasing globally. This has led to an increase in demand for bone grafts and substitutes, as these treatments can help alleviate the symptoms associated with these conditions.

However, bone grafts and substitutes procedures can be expensive, and this can limit their accessibility for some patients, thus restraining the growth of the market. In addition, some healthcare systems have limited reimbursement policies for bone grafts and substitutes procedures. This can make it difficult for patients to access these treatments, particularly if they do not have adequate insurance coverage. Moreover, potential risks associated with bone grafts and substitutes procedures, such as infection, rejection, and nerve damage, also restrains the growth of the market.

The outbreak of COVID-19 has disrupted workflows in the health care sector around the world. The disease has forced several industries to shut down temporarily, including several sub-domains of health care. The pandemic reduced accessibility to and patient attendance at outpatient medical visits, including preventive services such as screening of patients for various diseases such as orthopedic disorders. In addition, orthopedic doctors noted a marked decrease in patients visits during the lockdown. This was due to cancellation of medical treatments and postponing the orthopedic injuries to stop the spread of COVID-19 infection. For instance, according to report of Australian Orthopedic Association National Joint Replacement Registry 2021, stated that, joint replacement surgery declined by 5.7% in 2020 as compared to 2019. Thus, COVID-19 negatively impacted bone grafts and substitutes market, owing to less patient visits for diagnosis and monitoring orthopedic disorders. 

Segmental Overview

The bone grafts and substitutes market is segmented into type, application, end user and region. On the basis of type, the market is categorized into allografts, bone grafts substitute and cell-based matrices. On the basis of application, the market is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction and dental bone grafting. On the basis of end user, the market is classified into hospitals, specialty clinics and others. Region wise, the market is analyzed across North America (the U.S., Canada, and Mexico), Europe (Germany, France, the UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).

By Type

The market is categorized into allografts, bone grafts substitute and cell-based matrices. The allografts segment accounted for the largest bone grafts and substitutes market size in 2021, and is expected to remain dominant during the forecast period, owing to the properties such as immediate structural support and osteoconductive. In addition, availability of allografts in various size and shapes such as chips, pellets and granules result in adoption of allografts. The bone grafts substitute segment is projected to register highest CAGR during forecast period owing to rise in adoption of substitutes in bone related diseases and increase in product launches by key players of the market.

Bone Grafts and Substitutes Market by Type

By Application

The market is categorized into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction and dental bone grafting. The spinal fusion segment occupied the largest bone grafts and substitutes market share in 2021 and is expected to remain dominant during the forecast period owing to increase in geriatric population and rise in incidence of spinal disorders. The dental bone grafting segment is projected to register highest CAGR during the forecast period owing to increase in usage of bone grafts for dental procedures and availability of bone grafts for dental applications.

Bone Grafts and Substitutes Market by Application

  
By End User

The market is categorized into hospitals, specialty clinics and others. The hospitals segment occupied largest bone grafts and substitutes market share in 2021 and is expected to register highest CAGR owing to availability of advanced medical technologies, highly skilled healthcare professionals and a wide range of specialized services.

Bone Grafts and Substitutes Market by End user

By Region

The bone grafts and substitutes market is analyzed across North America, Europe, Asia-Pacific, and LAMEA. North America accounted for a majority of the global bone grafts and substitutes market share in 2021, and is anticipated to remain dominant during the forecast period. This is attributed to rise in prevalence of orthopedic disorders, prevalence of advanced healthcare infrastructure, and presence of key players offering bone grafts & substitutes. However, Asia-Pacific is anticipated to witness notable growth, owing to increase in number of joint disorders, rise in awareness about bone grafts, and surge in investments for development of advanced bone grafts. This is expected to drive the bone grafts and substitutes market growth during the forecast period.

Bone Grafts and Substitutes Market by Region

Asia-Pacific is expected to grow at the highest rate during the bone grafts and substitutes market forecast. The market growth in this region is attributable to presence of key players in the region. Moreover, rise in adoption of various bone grafts substitutes for dental disorders is expected to drive the growth of the market. In China, prevalence of arthritis is increasing leading to rise in demand for bone grafts, thereby driving the growth of the market. For instance, according to Frontiers in Pharmacology 2022, prevalence of rheumatoid arthritis is estimated to be 0.2–0.3% in China with approximately 3 million patients, thus rise in rheumatoid arthritis cases is expected to drive the growth of the market. Further, many countries such as Australia, awareness programs are organized every year to educate people about orthopedic disorders and available bone grafts. Thus, such awareness campaigns are expected to propel market expansion. Asia-Pacific offers profitable opportunities for key players operating in the bone grafts and substitutes market, thereby registering the fastest growth rate during the forecast period, owing to the surge in infrastructure of industries, rise in in spending for orthopedic disorders, as well as well-established presence of domestic companies in the region. In addition, rise in contract manufacturing organizations within the region provides great opportunity for new entrants in this region.  

Presence of several major players, such as Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings and advancement in manufacturing technology for development of advanced bone grafts in the region is expected to drive the growth of the bone grafts and substitutes market forecast. In addition, various private organizations organize educating camps for awareness of orthopedic disorders and available bone grafts across the globe, thereby driving the growth of the market. Furthermore, presence of well-established healthcare infrastructure, and rise in adoption rate of bone graft substitutes for treating dental and spinal injuries are expected to drive the market growth. Furthermore, various product approvals and contracts as key strategies adopted by the key players in this region further boost the growth of the bone grafts and substitutes industry.  


Competition Analysis

Competitive analysis and profiles of the major players in the bone grafts and substitutes market, such as Arthrex, Inc., Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., Xtant Medical Holdings, Inc., Integra LifeSciences and Orthofix Holdings, Inc. are provided in this report. Major players have adopted acquisition, product launch, product approval, partnership, strategic alliance and contract as key developmental strategies to improve the product portfolio of the bone grafts and substitutes industry.  

Some Examples Of Product Approval In The Market 

  • In July 2020, Baxter International Inc., received U.S. Food and Drug Administration (FDA) clearance for Altapore Shape Bioactive Bone Graft, the latest addition to the company’s next-generation bone graft substitute product line.

Some Examples Of Product Launch In The Market 

  • In August 2020, Xtant Medical Holdings, Inc. a global medical technology company focused on surgical solutions for the treatment of spinal disorders, announced the U.S. commercial launch of the Matriform Si, a silicated synthetic bone graft strip designed and cleared for spinal fusion procedures.

Some Examples Of Acquisition In The Market 

  • In January 2023, Zimmer Biomet Holdings, Inc., a global medical technology leader, announced that it has reached a definitive agreement to acquire Embody, Inc., a privately-held medical device company focused on soft tissue healing.

Some Examples Of Contract In The Market 

  • In July 2021, Integra LifeSciences Holding Corporation, a leading global medical technology company, announced its SurgiMend collagen matrix for soft tissue reconstruction has received an innovative technology contract from Vizient, Inc. the nation’s largest member-driven health care performance improvement company.

Key Benefits For Stakeholders

  • This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the bone grafts and substitutes market analysis from 2021 to 2031 to identify the prevailing bone grafts and substitutes market opportunities.
  • The market research is offered along with information related to key drivers, restraints, and opportunities.
  • Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
  • In-depth analysis of the bone grafts and substitutes market segmentation assists to determine the prevailing market opportunities.
  • Major countries in each region are mapped according to their revenue contribution to the global market.
  • Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
  • The report includes the analysis of the regional as well as global bone grafts and substitutes market trends, key players, market segments, application areas, and market growth strategies.

Bone Grafts and Substitutes Market Report Highlights

Aspects Details
Market Size By 2031
Market Size By 2031

USD 4 billion

Growth Rate
Growth Rate

CAGR of 4.5%

Forecast period
Forecast period

2021 - 2031

Report Pages
Report Pages

407

Bone Grafts and Substitutes Market By Type
By Type
  • Allografts
    • Type
      • Machined allografts
      • Demineralized bone matrix
  • Bone grafts substitutes
    • Type
      • Bone morphogenic proteins (BMP)
      • Synthetic bone grafts
  • Cell based matrices
Bone Grafts and Substitutes Market By Application
By Application
  • Spinal fusion
  • Trauma
  • Joint reconstruction
  • Dental bone grafting
  • Craniomaxillofacial
Bone Grafts and Substitutes Market By End user
By End user
  • Hospitals
  • Specialty clinics
  • Others
Bone Grafts and Substitutes Market By Region
By Region
  • North America  (U.S., Canada, Mexico)
  • Europe  (Germany, France, UK, Italy, Spain, Rest of Europe)
  • Asia-Pacific  (Japan, China, India, Australia, South Korea, Rest of Asia-Pacific)
  • LAMEA  (Brazil, Saudi Arabia, South Africa, Rest of LAMEA)
Key Market Players
Key Market Players

Baxter International Inc., Arthrex, Inc., Stryker Corporation, Orthofix Holdings, Inc., Johnson & Johnson, Medtronic plc, Zimmer Biomet Holdings, Inc., NuVasive, Inc., Xtant Medical Holdings, Inc., Integra LifeSciences

Analyst Review

This section provides various opinions of top-level CXOs in the global bone grafts and substitutes market. According to the insights of CXOs, increase in musculoskeletal conditions, advancements in medical technology leading to a shift from autograft to allograft, increased preference for biocompatible bone grafts, has surged the interest of several companies to develop novel medications.  

CXOs further added that rise in expenditure on the development of healthcare infrastructure and increase in personal disposable income are expected to boost the growth of the bone grafts and substitutes market. In addition, increase in burden of orthopedic disorders across the globe surges the demand for bone grafts & substitutes, thus driving the growth of the market. In addition, rise in number of key players offering bone grafts & substitutes is also anticipated to drive the growth of the market.  

Furthermore, North America accounted for a majority of the global bone grafts and substitutes market share in 2021, and is anticipated to remain dominant during the forecast period. This is attributed to rise in prevalence of orthopedic disorders, prevalence of advanced healthcare infrastructure, and presence of key players offering bone grafts & substitutes. Upsurge in healthcare expenditure in the emerging economies is anticipated to offer lucrative opportunities for the market expansion. However, Asia-Pacific is anticipated to witness notable growth, owing to increase in number of joint disorders, rise in awareness about bone grafts, and surge in investments for development of advanced bone grafts. 

Author Name(s) : Shraddha Mali | Roshan Deshmukh
Frequently Asked Questions?

Spinal fusion is the leading application of bone grafts and substitutes market.

Growth & innovations in the orthopedic sector for the manufacturing of advanced bone grafts & substitutes, are the upcoming trends of the market.

North America is the largest regional market for bone grafts and substitutes.

Arthrex, Inc., Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., and Orthofix Holdings, Inc., are the top companies to hold the market share in bone grafts and substitutes market.

The bone grafts and substitutes market was valued at $2,586.30 million in 2021, and is projected to reach $4,005.26 million by 2031, registering a CAGR of 4.5% from 2022 to 2031.

2021 is the base year of bone grafts and substitutes market.

2022 to 2031 is the forecast period of bone grafts and substitutes market.

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Bone Grafts And Substitutes Market

Global Opportunity Analysis and Industry Forecast, 2021-2031