Global Bone Grafts and Substitutes Market was valued at $2,443 million in 2015, and is expected to reach $3,397 million by 2022, registering a CAGR of 4.1% during the forecast period 2016‐2022. Bone grafts are implantable materials that promote bone healing, bone formation, and osseous reconstruction due to its osteoconductive, osteogenic, and osteoinductive properties. Bone grafting is a surgical procedure for replacing a missing or defected bone with a material (bone graft) from a patients own body, cadaver, animals, or a different person. Bone grafts are used in sports, trauma plastic, facial, and spinal surgery. Bone grafting finds its application in wound healing and complex fracture treatment, among others. Bone grafts can also be used to fill voids in case of absence of bones or help in provision of structural stability.
Increase in in incidence of bone & joint disorders, technological advancements in medical field, development of biocompatible synthetic bone grafts, increase in demand for dental bone grafts drive the bone grafts and substitutes market. However, high cost of surgeries and ethical issues related to bone grafting procedures hamper the market growth. Conversely, increase in focus of key players towards R&D activities in bone grafts and its substitutes and upsurge in demand for orthopedic procedures among geriatric population are expected to provide lucrative opportunities for the market players in the future.
BONE GRAFT AND SUBSTITUTES MARKET SEGMENTATION
According to AMR analysis, bone graft substitutes segment accounted for more than half of the overall market in 2015, and is expected to dominate the market during the forecast period. This is attributed to the increase in prevalence of bone and joint disorders. In addition, these bone graft substitutes are used in varied applications such as bone replacement, posttraumatic skeletal conditions, and other bone-related problems. Moreover, advancements in bone graft materials and development of innovative products have fueled the market growth.
BONE GRAFTS AND SUBSTITUTES MARKET, BY PRODUCT, 2015
LAMEA Bone Grafts and Substitutes Market
Increase in incidence of orthopedic disorders coupled with rapid growth in geriatric population drives the growth of the BGS market in the LAMEA region. However, the countries in Latin America have low gross income, therefore do not spend on the development of new methods and devices for the diagnosis and treatment of orthopedic disorders. Lack of healthcare facilities and increased need for treatment devices for orthopedic disorders have increased the penetration of major players in the Middle East region. Nevertheless, the market growth is driven by improving healthcare infrastructure coupled with rise in disposable income.
Top Impacting Factors
TOP IMPACTING FACTORS: BONE GRAFTS AND SUBSTITUTES MARKET
Increasing incidence of musculoskeletal conditions
Increase in incidence of musculoskeletal conditions has increased the usage of bone grafts and their substitutes in the market. Bone graft is an ideal mode of treatment for complex skeletal defects. Musculoskeletal conditions include a variety of disorders that affect muscles, bones, and joints. Arthritis, low back pain, fibromyalgia, and gout tendinitis are the different forms of musculoskeletal disorders. The risks associated with musculoskeletal conditions increase with age, lack of physical activity, and obesity. Musculoskeletal diseases affect the adult population. According to National Health Interview Survey, in 2012, around 126 million adults were affected by this disease in the U.S. According to Labor Force Survey (LFS), about 553,000 cases were registered for all work-related musculoskeletal disorder out of the total of 1,243,000 cases.
Technological advancements in medical devices leading to shift from autograft to allograft procedures
Over the past few years, bone grafts and substitutes market size has witnessed remarkable growth due to technological advancements in the medical field. Technological advancements in this sector have increased the array of grafting materials, including xenograft, allograft, and synthetic materials. Synthetic grafts products and expensive demineralized bone matrix are alternatives to autografts.
Development of biocompatible synthetic bone grafts
Increase in demand for biocompatible grafts has increased the interest and efforts of companies to develop comprehensive orthobiologic platforms. Biocompatible bone grafts do not face the issue of rejection from host, hence, the development of biocompatible synthetic bone grafts is one of the major trends observed in the market. The development of biocompatible bone graft materials has reduced such failures and enhanced normal bone formation rate in hosts. The market has witnessed the development of many biocompatible bone grafts and their substitutes (such as B-OstIN and hydroxyapatite allografts). As per Basic Healthcare Products, B-OstIN has been implanted with minimum 12 months of follow-up in 500 patients, and has shown no adverse effects. Thus, the development of biocompatible bone grafts has provided an ideal substitute to autogenous bone grafts.
Obesity and diabetes to increase the risk of degenerative joint diseases
Increase in prevalence of obesity and diabetes is set to drive the demand for bone grafts and bone substitutes, worldwide. Aliments, such as diabetes and obesity, increase the risk of degenerative joint disease manifold. According to the Report Global Burden of Disease, WHO, it is estimated that about 285 million people suffered from diabetes in 2010, and this is estimated to increase to 438 million by 2030. People with diabetes are prone to suffer from osteoporosis and joint disorders. Similarly, a person with obesity faces 60% more chances of developing arthritis and other joint disorders.
High cost of surgeries
Bone grafting, spinal fusion, and joints reconstruction incur high cost. For instance, as per ECRI Institute, more than $19 billion is spent on bone grafts and implant bone graft supplies. Moreover, a simple grafting procedure using bone from cadavers or cow costs about $200‐$1,200 for a single implant area. Thus, the high cost of surgeries is expected to hamper the market growth.
Ethical issues related with bone grafting procedures
Bone grafting involves the use of allografts and xenografts, which are transplanted from another donor of same or different species, and are obtained from human and animal cadavers. The refusal rate of allograft grating procedures among patients is high due to ethical issues. For instance, a study conducted by BMC Medical Ethics states that out of the sample of 100 patients, about 20% of the patients refuse to accept allografts for their grafting surgery. The reason for this was specific religious affiliations. For instance, Hinduism does not support the use of allografts from cow and pigs. Moreover, certain patients do not accept allografts from human remains.
The major players operating in this market include Medtronic plc, Stryker Corporation, DePuy Synthes, Integra Lifesciences Holdings Corporation, Wright Medical Group N.V., Zimmer Biomet Holdings, Inc., Xtant Medical Holdings, Inc. (Bacterin), Arthrex, Inc., Baxter International Inc., and Musculoskeletal Transplant Foundation (MTF). The other players (profiles not included in the report) in the value chain include NovaBone Products, LLC, BonAlive Biomaterials Ltd., Sigma Graft Biomaterials, Pioneer Surgical Technology Inc., RTI Biologics, Inc., Orthofix International N.V., Citagenix Inc., Heraeus Medical GmbH, Graftys SA, and NuVasive, Inc.
BONE GRAFTS SUBSTITUTES MARKET KEY BENEFITS
- The report provides an in-depth analysis of the market along with current bone grafts and substitutes market trends and future estimations to elucidate the imminent investment pockets.
- The report provides a quantitative analysis for the period of 20142022 to enable stakeholders to capitalize on the prevailing market opportunities.
- Extensive analysis of the market based on product helps in understanding the type of devices used to treat musculoskeletal disorders and degenerative joints diseases.
- Competitive intelligence highlights the business practices followed by leading players across various regions.
- Comprehensive analysis of the geographical regions helps to determine the prevailing opportunities in these regions.
- Key market players and their strategies have been analyzed to understand the competitive outlook of the global market.
- Extensive analysis of the bone grafts and substitutes market share is conducted by following key product positioning and by monitoring the top contenders within the market framework.
BONE GRAFTS SUBSTITUTES MARKET KEY SEGMENTS
- Machined Allografts
- Demineralized Bone Matrix
- Bone Grafts Substitutes
- Bone Morphogenic Proteins (BMP)
- Synthetic Bone Grafts
- Cell-based Matrices
- Spinal Fusion
- Joint Reconstruction
- Dental Bone Grafting
- North America
- Rest of Europe
- South Korea
- Rest of Asia-Pacific
- South Africa
- Saudi Arabia
- Rest of LAMEA