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Fluorescence In-situ Hybridization (fish) Probe Market

Fluorescence In-situ Hybridization (FISH) Probe Market: Global Opportunity Analysis and Industry Forecast, 2020-2027

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Dec 2021 | 295 Views
Author(s) : Onkar Sumant
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Fluorescence in situ hybridization (FISH) is a macromolecule recognition technique, which is considered as a new advent in the field of cytology. Initially, it was developed as a physical mapping tool to delineate genes within chromosomes. The accuracy and versatility of FISH were subsequently capitalized upon in biological and medical research. This visually appealing technique provides an intermediate degree of resolution between DNA analysis and chromosomal investigations. FISH consists of a hybridizing DNA probe, which can be labelled directly or indirectly. In the case of direct labelling, fluorescent nucleotides are used, while indirect labelling is incorporated with reporter molecules that are subsequently detected by fluorescent antibodies or other affinity molecules. FISH is applied to detect genetic abnormalities that include different characteristic gene fusions or the presence of an abnormal number of chromosomes in a cell or loss of a chromosomal region or a whole chromosome. It is also applied in different research applications, such as gene mapping or the identification of novel oncogenes.

Market scope and structural analysis:

Report Metric


  Market size available for years


  Base year considered


  Forecast period


  Forecast units

  Value (USD)

  Segments covered

  Probe Type, Application, End-users, Region.

  Regions covered

•North America (U.S., Canada, Mexico)

•Europe (France, Germany, UK, Italy, Spain, Rest of Europe)

•Asia-Pacific (Japan, China, India, Australia, South Korea, Rest of Asia-Pacific)

•LAMEA (Brazil, South Arabia, South Africa, Rest of LAMEA)

  Companies covered

Creative-Biolabs, Abnova Corporation, Thermo Fisher Scientific Inc., Agilent Technologies, Genemed Biotechnologies, Inc., F. Hoffman-La Roche AG, Biosearch Technologies, Inc., Mirus Bio LLC, Horizon Diagnostics, and Oxford Gene Technology.


Covid-19 Scenario analysis:

COVID-19 (Coronavirus disease 2019) is caused by the positive stranded SARS-CoV-2 RNA virus in humans and is closely related to the bat-derived severe acute respiratory syndrome-like coronaviruses. Among the human viruses SARS-CoV-2 is most similar to SARS-CoV and MERS-CoV viruses that are responsible for the severe acute respiratory syndrome and Middle Eastern respiratory syndrome, respectively. The unparalleled sensitivity and specificity of the RNAscope technology allows direct visualization of the virus and estimates the viral load in any tissue and cells with morphological context. This technology eliminates the need for the costly and time-consuming development of specific antibodies for newly identified gene targets or pathogens such as the COVID-19 SARS-CoV-2 virus. Additionally, the RNAscope technology can be combined with immunohistochemistry (IHC) on the same slide for detection of RNA and protein simultaneously. The RNAscope probe can detect the SARS-CoV-2 spike protein mRNA and does not detect other coronaviruses. Thus the development and need of probe technology is driving the market.

Top impacting factors: Market Scenario Analysis, Trends, Drivers and Impact analysis:


Technologically advance for detection of multiple diseases:

The global fluorescent in situ hybridization probes market is projected to be driven by high prevalence and rise in incidence rates of cancer and genetic disorders across the globe. FISH is a less time-consuming technique in comparison to the conventional method of cytogenetic metaphase karyotype analysis because, in the former, the detection technique involves processing with either fresh water or paraffin-embedded interphase nuclei without the need of culturing. By using this technique, specific cytogenetic abnormalities, as well as a copy of aberrations numbers, can be enumerated and sketched. For example, chromosomal micro deletion, amplification, and subsequently, translocation can easily be detected through FISH. The improved diagnostic techniques have made the treatment easier and increased the life expectancy of people. Examples of diseases that are diagnosed using FISH include Prader-Willi syndrome, Angelman syndrome, 22q13 deletion syndrome, chronic myelogenous leukemia, acute lymphoblastic leukemia, Cri-du-chat, Velocardiofacial syndrome, and Down syndrome. FISH on sperm cells is indicated for men with an abnormal somatic or meiotic karyotype as well as those with oligozoospermia, since approximately 50% of oligozoospermia men have an increased rate of sperm chromosome abnormalities. The analysis of chromosomes 21, X, and Y is enough to identify oligozoospermia individuals at risk. Therefore, FISH is becoming a more vital tool to detect and monitor the specific therapy with regards to the gene abnormalities; for example, the detection of the BCR/ALB1 translocation in chronic myeloid leukemia, human epidermal growth factor receptor 2 (HER2) augmentation in breast cancer, and anaplastic lymphoma kinase (ALK) rearrangement in adenocarcinoma these detections and advancement of the FISH probe is driving the market.

Increase in clinical studies:

FISH is often used in clinical studies. If a patient is infected with a suspected pathogen, bacteria, from the patient's tissues or fluids, are typically grown on agar to determine the identity of the pathogen. Many bacteria, however, even well-known species, do not grow well under laboratory conditions. FISH can be used to detect directly the presence of the suspect on small samples of patient's tissue. FISH can also be used to compare the genomes of two biological species, to deduce evolutionary relationships. A similar hybridization technique is called a zoo blot. Bacterial FISH probes are often primers for the 16s rRNA region. FISH is widely used in the field of microbial ecology, to identify microorganisms. Biofilms, for example, are composed of complex (often) multi-species bacterial organizations. Preparing DNA probes for one species and performing FISH with this probe allows one to visualize the distribution of this specific species within the biofilm. Preparing probes (in two different colors) for two species allows researchers to visualize/study co-localization of these two species in the biofilm and can be useful in determining the fine architecture of the biofilm. Thus the rise in research is creating the drive in the market.


Virtual karyotyping is another cost-effective, clinically available alternative to FISH panels using thousands to millions of probes on a single array to detect copy number changes, genome-wide, at unprecedented resolution. The development of alternative technique is hampering the market growth. Also, there are large financial costs associated with the fish probe, the existence of variations in the regulations for the development and usage of these probes depending on the differing regions, also the absence of skilled professionals to interact and utilize this technology from the various underdeveloped regions, these factors are expected to restrain the growth of the market.

Regional analysis:

North America is projected to account for the largest share of the global Fluorescent In Situ Hybridization Probes market owing to high prevalence of cancer especially breast cancer, well-established R&D infrastructure, high clinical R&D budgets, and presence of large number clinical research organization. Europe is anticipated to account for the second largest market share by 2026. The fluorescent in situ hybridization probes market in Europe is expected to grow at a rapid pace during the forecast period. The Fluorescent In Situ Hybridization Probes market is Asia Pacific is likely to expand at a moderate CAGR during the forecast period owing to large population with cancer and genetic disorders, increase in investments in the biotechnology industry in the emerging countries such as India and China, and rise in clinical R&D activities in the region.

Key segments covered:



  Probe Type

  • Locus Specific Probes
  • Alphoid/Centromere Repeat Probes
  • Whole Chromosome Probes


  • Cancer Research
    • Lung
    • Breast
    • Bladder
    • Hematological
    • Gastric
    • Prostate
    • Cervical
    • Others
  • Genetic Diseases
  • Others

  End Users

  • Research Organizations
  • Clinical Organizations
  • Biotechnology Companies
  • Companion Diagnostics
  • Academic & Research Institutes


  • North America
  • Europe
  • Asia-Pacific


Key benefits of the report:

  • This study presents the analytical depiction of the global Fluorescence In-situ Hybridization (FISH) Probe industry along with the current trends and future estimations to determine the imminent investment pockets.
  • The report presents information related to key drivers, restraints, and opportunities along with detailed analysis of the global Fluorescence In-situ Hybridization (FISH) Probe market share.
  • The current market is quantitatively analyzed from 2020 to 2027 to highlight the global Fluorescence In-situ Hybridization (FISH) Probe market growth scenario.
  • Porter’s five forces analysis illustrates the potency of buyers & suppliers in the market.
  • The report provides a detailed global Fluorescence In-situ Hybridization (FISH) Probe market analysis based on competitive intensity and how the competition will take shape in coming years.

Questions answered in the Fluorescence In-situ Hybridization (FISH) Probe Market research report:

  • What are the leading market players active in the Fluorescence In-situ Hybridization (FISH) Probe market?
  • What the current trends will influence the market in the next few years?
  • What are the driving factors, restraints, and opportunities in the market?
  • What are the projections for the future that would help in taking further strategic steps?
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