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Male Infertility Market by Techniques (DNA Fragmentation Technique, Oxidative Stress Analysis, Microscopic Examination, Sperm Penetration Assay, Sperm Agglutination, Computer Assisted Semen Analysis) - Global Opportunity Analysis and Industry Forecast, 2012 - 2020

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Pages: 80
Apr 2014 | 5323 Views
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Author's : Debbie Shields
Tables: 24
Charts: 12
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Male infertility Market Overview:

Male Infertility Market was valued at $216 million, and is expected to reach $301.5 million by 2020, supported by a CAGR of 5%. The inability of a couple to conceive within 12 months of unprotected intercourse is called infertility. According to National Institutes of Health in the U.S. there are approximately >2 million infertile couples of which about 40% accounts to male infertility. The most common type of male infertility is the idiopathic infertility and infertility due to varicocele. The basic treatments involved in male infertility are surgery, treatment for problems in intercourse, hormone treatment and ART technology.

There is a steady increase in the global infertility rates both in the developed and developing nations. The changing life style, delayed pregnancy and aging are few of the factors driving the global infertility cases. The report excludes basic male infertility treatments such as surgery, treatment for problems in intercourse and hormonal treatment. The report focuses on male infertility and its treatment techniques with focus on drugs and devices. There are various techniques that are used in the diagnosis of the male infertility such as DNA fragmentation, oxidative stress, CASA (computer assisted semen analysis), sperm penetration assay, sperm agglutination and microscopic examination. The DNA fragmentation is an emerging technique which has already gained popularity and is accepted as a routine technique in the developed countries. The technique is yet to gain popularity in the developing regions and yet to be used as a routine technique due to the cost hindrance.

Types of male disorders, 2015 (%)

Male Disorder by Type 2015

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The couple’s inability to conceive within one year of unprotected intercourse is defined as infertility. Approximately 15% of couples in North America and Europe in a given year are unable to conceive.

Fertility depends on male, female and both male and female factors. Among the infertility cases, 8% cases are due to male factors, 37% cases are due to female factors, 35% cases are both female and male factors and 5% cases are unexplained factors in both the genders.

Causes of male infertility

Fertility in male is defined as the normal functioning of the pituitary gland, hypothalamus and testes. Thus, various conditions can lead to infertility:

  • 1-2% of the cases are due to problems in the hypothalamus
  • 10-20% of the cases are due to blockage of the sperm pathway 
  • 30-40% of the cases are due to improper functions of the testes 
  • 40%-50% of the cases are unidentifiable 

Evaluation of male infertility

An evaluation is done by studying the patient’s health and medical history. Physical examination comes under the evaluation tests which includes the measurement of weight, height, muscle distribution, assessment of body fat, visual observation of breasts and genitals and inspection of hair pattern and skin. For example, in cases of testosterone deficiency, there is loss of body and facial hair with decrease in testis size. The various other conditions that affect fertility are absence of vas deferens, varicocele and epididymis thickening.

Male Infertility Market

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The semen analysis technique is done to check the fertility level of the collected semen sample and to identify the reasons for infertility. The various techniques used in semen analysis are 
    DNA fragmentation
    Oxidative stress analysis 
    Sperm penetration assay
    Sperm agglutination assay
    Computer assisted semen analysis (CASA)
    Sperm agglutination
    Microscopic examination
    Others (biochemical assessment tests)

The DNA fragmentation technique and oxidative stress analysis test has a significant usage in the semen analysis technique. The DNA fragmentation test is expected to be the most widely used in the routine semen analysis test, when compared to the oxidative stress analysis test. This is due to DNA fragmentation test’s ability to measure DNA damage example SCSA (Sperm chromatin structure assay) a method used in DNA fragmentation testing, is a sensitive one and can measure DNA damage in 20% of couples with unexplained infertility. The oxidative stress analysis is not widely used as DNA fragmentation due to the alternative methods such as IVF/ICSI, for achieving pregnancy. The microscopic examination test is a routine mandatory test used in all cases, but the test is expected to be replaced by the CASA due to its automation.

Key Benefits

  • The report provides detailed analysis about the driving and limiting factors of the male infertility market, which would give a deeper understanding of the subject and help in taking actionable decisions. 
  • The market size of the male infertility diagnostic and treatments will help in analyzing the market, thus helping the stakeholders understand opportunities  in the male infertility market 
  • Market share analysis of both male and female infertility treatments that allow the decision makers to gauge the market strength and make profitable investments 
  • The report analyzes the market condition in a comprehensive and quantitative manner and forecast market trends and techniques used in male infertility treatments 

Reason for the Study

  • To study the various techniques used to treat male infertility
  • To identify the benefits of the new techniques over the conventional techniques
  • To study the treatment trends in various geographic regions

Male Infertility Market Key Segments

The global male infertility market is segmented based on techniques and geography.

By Techniques

  • DNA Fragmentation Technique
  • Oxidative Stress Analysis
  • Microscopic Examination
  • Sperm Penetration Assay
  • Sperm Agglutination
  • Computer Assisted Semen Analysis 
  • Others

By Geography

  • North America
  • Europe
  • Asia Pacific
  • RoW
 

Chapter: 1. INTRODUCTION

1.1 Key deliverables
1.2 Research Methodology

1.2.1 Secondary research
1.2.2 Primary research
1.2.3 Analyst tools and models

Chapter: 2. EXECUTIVE SUMMARY

Chapter: 3. MARKET SIZING

3.1 Market definition

3.1.1 Basics of infertility treatment techniques

3.1.1.1 Surgery

3.1.1.1.1 VARICOCELECTOMY
3.1.1.1.2 OTHER SURGICAL METHODS

3.1.1.2 Treatment for problems in intercourse.

3.1.1.2.1 ERECTILE DYSFUNCTION
3.1.1.2.2 PREMATURE EJACULATION

3.1.1.3 Hormone treatment

3.1.1.3.1 HORMONAL AGENTS
3.1.1.3.2 NON-HORMONAL AGENTS

3.1.1.4 ART technology

3.1.1.4.1 TESTICULAR FINE NEEDLE ASPIRATION
3.1.1.4.2 MICROSURGICAL EPIDIDYMAL SPERM ASPIRATION
3.1.1.4.3 TESTICULAR SPERM EXTRACTION
3.1.1.4.4 TESTICULAR SPERM ASPIRATION

3.1.1.5 Treatment for Retrograde Ejaculation and Failure of Emission
3.1.1.6 Vasectomy Reversal (Vasovasostomy)
3.1.1.7 Reversal vasectomy versus ART

3.2 Male infertility market drivers

3.2.1 Life style issues
3.2.2 Environmental factors
3.2.3 Advancement in technology
3.2.4 Physical causes
3.2.5 Rise in infertility rates
3.2.6 Age

3.3 Male infertility market restraints

3.3.1 Impact of repeated failures in treatments
3.3.2 Social taboos

3.4 Challenges and opportunities

3.4.1 Medical tourism
3.4.2 Increased awareness level may lead to market growth

3.5 Demand analysis

3.5.1 Level of infertility couples (males versus female)
3.5.2 Number of couple who opt for infertility diagnostics
3.5.3 Total population under IVF treatment
3.5.4 Success rate for IVF treatment

3.6 Male versus Female infertility treatment market
3.7 Market size for male infertility diagnostics market

3.7.1 Global male infertility market by techniques
3.7.2 Global male infertility techniques market by geography
3.7.3 Market size for male infertility treatments market

Chapter: 4. CONSIDERATIONS AND PROCESS MALE INFERTILITY & IVF TREATMENT

4.1 Causes of male infertility
4.2 Evaluation of male infertility
4.3 Semen Analysis

4.3.1 Lab testing
4.3.2 Blood tests
4.3.3 Genetic tests
4.3.4 Other tests

4.4 Treatments of male infertility

4.4.1 Reproductive tract blockage
4.4.2 Gonadotropin treatment
4.4.3 Varicocele
4.4.4 Others

4.5 ART for male infertility

4.5.1 IVF
4.5.2 ICSI
4.5.3 TESE (testicular extraction of sperm)
4.5.4 Limitation of ART
4.5.5 Emotional support during infertility treatment

Chapter: 5. SEMEN ANALYSIS TECHNIQUES MARKET SIZE AND ANALYSIS

5.1 DNA fragmentation

5.1.1 Introduction
5.1.2 When and why is DNA fragmentation conducted
5.1.3 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments
5.1.4 Available tests for sperm DNA fragmentation

5.1.4.1 SCSA (Sperm chromatin structure assay)
5.1.4.2 TUNEL assay
5.1.4.3 Halo test
5.1.4.4 Comet assay
5.1.4.5 Unexplained infertility treatment

5.1.5 DNA testing benefits
5.1.6 Sperm DNA damage and reproductive outcomes
5.1.7 Limitations
5.1.8 Global male infertility DNA fragmentation market by geography, 2012-2020 ($Million)

5.2 Oxidative stress analysis

5.2.1 ROS induced DNA damage and apoptosis
5.2.2 Reasons for oxidative stress
5.2.3 Lifestyle changes

5.2.3.1 Consumption of alcohol
5.2.3.2 Smoking
5.2.3.3 Psychological stress

5.2.4 Aging
5.2.5 Infection MAGI (Male accessory sex gland infection)
5.2.6 Environmental Factors

5.2.6.1 Electromagnetic radiation
5.2.6.2 Toxins and chemicals
5.2.6.3 Iatrogenic
5.2.6.4 Chemotherapy and Drugs
5.2.6.5 Varicocele

5.2.7 When and why oxidative stress analysis test is conducted
5.2.8 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments
5.2.9 Available tests for Oxidative stress analysis

5.2.9.1 Chemiluminescence
5.2.9.2 Lipid peroxidation markers
5.2.9.3 Measurement of oxidative DNA damage
5.2.9.4 Other methods of ROS measurement
5.2.10 Global male infertility oxidative stress market by geography, 2012-2020 ($Million)

5.3 Sperm penetration assay

5.3.1 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments

5.3.1.1 The reasons for the tests
5.3.1.2 Sperm Penetration Tests
5.3.1.3 Sperm Mucus Penetration Test
5.3.1.4 Sperm Penetration Assay

5.3.2 Global male infertility sperm penetration assay market by geography, 2012-2020 ($Million)

5.4 Computer assisted semen analysis

5.4.1 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments
5.4.2 Functions of computer assisted sperm analysis
5.4.3 Global male infertility CASA market by geography, 2012-2020 ($Million)

5.5 Sperm Agglutination

5.5.1 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments

5.5.1.1 MAR test
5.5.1.2 Immunobead Binding
5.5.1.3 Diagnosis

5.5.2 Global male infertility sperm agglutination market by geography, 2012-2020 ($Million)

5.6 Microscopic examination

5.6.1 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments

5.6.1.1 Sperm concentration

5.6.2 Global male infertility microscopic examination market by geography, 2012-2020 ($Million)

5.7 Others

5.7.1 Consistency and accuracy of data generated from the tests and importance in deciding the ART treatments
5.7.2 Global male infertility others market by geography, 2012-2020 ($Million)

Chapter: 6. GLOBAL MALE INFERTILITY MARKET BY GEOGRAPHY

6.1 North America

6.1.1 North American male infertility market, 2012-2020

6.2 Europe

6.2.1 Europe male infertility market, 2012-2020

6.3 Asia pacific

6.3.1 Asia pacific male infertility market, 2012-2020

6.4 RoW

6.4.1 RoW male infertility market, 2012-2020

Chapter: 7. COMPANY PROFILES

7.1 EMD Serono, Inc.

7.1.1 Company overview
7.1.2 Company snapshot
7.1.3 Business performance

7.2 Cadila Healthcare Ltd. (ZydusCadila group)

7.2.1 Company overview
7.2.2 Company snapshot

7.3 ASKA pharmaceuticals, Inc.

7.3.1 Company overview
7.3.2 Company snapshot
7.3.3 Business performance
7.3.4 Strategic moves and developments

7.4 Intas pharmaceuticals Ltd.

7.4.1 Company overview
7.4.2 Company snapshot
7.4.3 Business performance

7.5 Pantarhei Bioscience B.V.

7.5.1 Company overview
7.5.2 Company snapshot

7.6 Cordex Pharma, Inc.

7.6.1 Company overview
7.6.2 Company snapshot

7.7 Halotech DNA SL

7.7.1 Company overview
7.7.2 Company snapshot
7.7.3 Financial Performance

7.8 SCSA diagnostics, Inc.

7.8.1 Company overview
7.8.2 Company snapshot
7.8.3 Financial Performance

7.9 Andrology solutions

7.9.1 Company overview
7.9.2 Company snapshot

7.10 Access Pharmaceuticals, Inc.

7.10.1 Company overview
7.10.2 Company snapshot
7.10.3 Business performance

 

LIST OF TABLES

TABLE 1 GLOBAL MALE INFERTILITY TECHNIQUES MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 2 GLOBAL MALE INFERTILITY MARKET BY TECHNIQUES,2012-2020 ($MILLION)
TABLE 3 GLOBAL MALE INFERTILITY TECHNIQUES MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 4 GLOBAL MALE INFERTILITY DNA FRAGMENTATION MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 5 GLOBAL MALE INFERTILITY OXIDATIVE STRESS MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 6 GLOBAL MALE INFERTILITY SPERM PENETRATION ASSAY MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 7 GLOBAL MALE INFERTILITY CASA MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 8 GLOBAL MALE INFERTILITY SPERM AGGLUTINATION MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 9 GLOBAL MALE INFERTILITY MICROSCOPIC EXAMINATION MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 10 GLOBAL MALE INFERTILITY OTHERS MARKET BY GEOGRAPHY, 2012-2020 ($MILLION)
TABLE 11 NORTH AMERICAN MALE INFERTILITY MARKET, 2012-2020 ($MILLION)
TABLE 12 EUROPE MALE INFERTILITY MARKET, 2012-2020 ($MILLION)
TABLE 13 ASIA PACIFIC MALE INFERTILITY MARKET, 2012-2020 ($MILLION)
TABLE 14 ROW MALE INFERTILITY MARKET, 2012-2020 ($MILLION)
TABLE 15 EMD SERONO, INC BUSINESS SNAPSHOT
TABLE 16 ASKA PHARMACEUTICALS, INC BUSINESS SNAPSHOT
TABLE 17 ASKA PHARMACEUTICALS, INC BUSINESS SNAPSHOT
TABLE 18 ASKA PHARMACEUTICALS, INC BUSINESS SNAPSHOT
TABLE 19 PANTARHEI BIOSCIENCE B.V. BUSINESS SNAPSHOT
TABLE 20 CORDEX PHARMA, INC. BUSINESS SNAPSHOT
TABLE 21 HALOTECH DNA SL BUSINESS SNAPSHOT
TABLE 22 SCSA DIAGNOSTICS, INC. BUSINESS SNAPSHOT
TABLE 23 ANDROLOGY SOLUTIONS BUSINESS SNAPSHOT
TABLE 24 ACCESS PHARMACEUTICALS, INC. BUSINESS SNAPSHOT

 

LIST OF FIGURES

FIG. 1 TYPES OF MALE DISORDERS
FIG. 2 CONVENTIONAL, CURRENT AND ADVANCED TREATMENTS FOR MALE INFERTILITY
FIG. 3 PERCENTAGE OF RETRIEVALS WHICH RESULTED IN LIVE BIRTHS AMONG COUPLES WITH DIAGNOSED MALE FACTOR INFERTILITY USING IVF WITH ICSI (2010)
FIG. 4 MARKET SHARE OF MALE AND FEMALE INFERTILITY TREATMENT 2013-2020
FIG. 5 MARKET SHARE OF MALE VERSUS FEMALE INFERTILITY TREATMENT MARKET (PERCENTAGE SHARE 2013-2020)
FIG. 6 MARKET SIZE FOR MALE INFERTILITY TREATMENTS MARKET, 2013-2020 ($MILLION)
FIG. 7 LEVEL OF FRAGMENTED DNA
FIG. 8 NUMBER OF DELIVERIES WITH OR WITHOUT MEASURING FRAGMENTATION
FIG. 9 SALES BY REGION, 2012
FIG. 10 HALOTECH DNA SL REVENUE BY YEAR (2012-2013)
FIG. 11 SCSA DIAGNOSTICS, INC. REVENUE BY YEAR (2012-2013)
FIG. 12 ACCESS PHARMACEUTICALS, INC. REVENUE BY YEAR (2011-2012)

 

Male infertility is defined as the inability of a man to impregnate his female partner after a year of unprotected intercourse. There are various types of infertilities such as idiopathic infertility, hormone deficiency, sperm autoimmunity, obstructive azoospermia, etc. The factors driving the male infertility market are the changing lifestyles which include the delaying of fathering children, consumption of alcohol, smoking, obesity, etc. The other factors being environmental factors and age related factors. The quality of the sperm decreases as individual ages, i.e. after 40years. The major limitation of the market is the repeated failures in treatment cycles that would lead to physical and emotional impact on the patient, and few patients would discontinue the treatments. The other limitation being the social taboo due to which the patients might not opt for treatment. Only 15% of infertile male opt for infertility treatment, this low percentage is due to the guilt and embarrassment felt by the patients and their unwillingness to speak about it. The opportunity of this market is the increase in awareness levels as most men are slowly opting for infertility treatment. The other opportunity of this market is medical tourism.

This market research report is an effort to provide the clear picture of the state of the market and sub markets over the next seven years. The report provides micro level analysis of the factors affecting the market, key market trends and industry drives and challenges for the better understanding of the market structure. The presentation of the market dynamics, competitive scenario and developments will enable marketers to aptly design their growth strategies and have competitive edge. Moreover, assessment of the top investment pockets and winning strategies will help in channelizing their investments in the right directions to garner better proceeds.

 

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