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Optogenetics Market: Global Opportunity Analysis and Industry Forecast, 2020-2027

A10906
Pages: NA
Jun 2021 | 70 Views
 
Author(s) : Onkar Sumant
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Optogenetics Market Outlook – 2027

In order to figure out how the brain works, scientists have had to do lots of experiments and figure out ways to examine and test the brain. In 2005, a new technique was created, called optogenetics. This technique uses a combination of light and genetic engineering (changing the genetic information of a living thing by inserting or deleting information in the genetic code) to control the cells of the brain. Optogenetics has become very popular and is now being used in brain research laboratories all over the world. It is helping us to discover many new things about the brain. Optogenetics most commonly refers to a biological technique that involves the use of light to control neurons that have been genetically modified to express light-sensitive ion channels. As such, optogenetics is a neuromodulator method that uses a combination of techniques from optics and genetics to control the activities of individual neurons in living tissue even within freely-moving animals. In some usages, optogenetics also refers to optical monitoring of neuronal activity and control of biochemical pathways in non-neuronal cells, although these research activities preceded the use of light-sensitive ion channels in neurons. As optogenetics is used by some authors to refer to only optical control of the activity of genetically defined neurons and not these additional research approaches, the term optogenetics is an example of polysemy.

Market scope and structural analysis:

Report Metric

Details

  Market size available for years

  2019–2027

  Base year considered

  2019

  Forecast period

  2020–2027

  Forecast units

  Value (USD)

  Segments covered

  Sensor Type, Application, End-users, Region.

  Regions covered

•North America (U.S., Canada, Mexico)

•Europe (France, Germany, UK, Italy, Spain, Rest of Europe)

•Asia-Pacific (Japan, China, India, Australia, South Korea, Rest of Asia-Pacific)

•LAMEA (Brazil, South Arabia, South Africa, Rest of LAMEA)

  Companies covered

Coherent Inc., Regenxbio Inc Thorlabs Inc, Noldus, Scientifica and Addgene.

 

Covid-19 Scenario analysis:

As economies around the world are suffering from the impact of Covid-19, businesses are experiencing losses, workers are without jobs, and many face the challenge of a complete upheaval of lifestyle. However, pharmaceutical companies taking center stage in the Covid-19 fight are seeing positive growth on the stock market and a new burst of innovation in the infectious disease landscape as the race for treatment approval for a Covid-19 therapy takes off. As economies around the world are suffering from the impact of Covid-19, businesses are experiencing losses, workers are without jobs, and many face the challenge of a complete upheaval of lifestyle. However, pharmaceutical companies taking center stage in the Covid-19 fight, such as Gilead and Eli Lilly, are seeing positive growth on the stock market and a new burst of innovation in the infectious disease landscape as the race for treatment approval for a Covid-19 therapy takes off. The COVID-19 has caused a pause on the non-essential therapies that take place in the hospital to reserve beds for COVID-19 patients and hence the optogenetics market may observe some upheaval.

Top impacting factors: Market Scenario Analysis, Trends, Drivers and Impact analysis:

Drivers:

Technological advancements:

Optogenetics has ushered in a new era of potent and targeted control over multiple aspects of neural function. Genetic and optical methods applied together allow tight spatial and temporal control of the activity of specific kinds of neurons in the living brain, a revolutionary advance that will allow us to achieve an unprecedented understanding of neural circuit function in behaving animals. Optogenetics provides millisecond-scale temporal precision which allows the experimenter to keep pace with fast biological information processing (for example, in probing the causal role of specific action potential patterns in defined neurons). Indeed, to probe the neural code, optogenetics by definition must operate on the millisecond timescale to allow addition or deletion of precise activity patterns within specific cells in the brains of intact animals, including mammals. By comparison, the temporal precision of traditional genetic manipulations (employed to probe the causal role of specific genes within cells, via "loss-of-function" or "gain of function" changes in these genes) is rather slow, from hours or days to months. It is important to also have fast readouts in optogenetics that can keep pace with the optical control. This can be done with electrical recordings ("optrodes") or with reporter proteins that are biosensors, where scientists have fused fluorescent proteins to detector proteins. An example of this is voltage-sensitive fluorescent protein (VSFP2). Additionally, beyond its scientific impact optogenetics represents an important case study in the value of both ecological conservation (as many of the key tools of optogenetics arise from microbial organisms occupying specialized environmental niches), and in the importance of pure basic science as these opsins were studied over decades for their own sake by biophysicists and microbiologists, without involving consideration of their potential value in delivering insights into neuroscience and neuropsychiatric disease. New developments in optogenetics such as wireless microchips have enabled convenient treatment of conditions, including depression and Parkinson’s disease. These advancements of brain mapping by optogenetics is the main driver for market.

Ability for treatment of depression

Depression is the most common life-threatening mental disorder. Although the study on depression was carried out for a long term, the fundamental mechanisms are mostly unrevealed. Antidepressants, that are common, are very effective in a few patients but it shows the side effects in noradrenergic and serotonin neurotransmission in some people with 28% efficacy. Nearly 30%–40% of the people are resistant to treatment for depression. These patients can be treated with optogenetics. The changes in activity of neurons cause panic, distress, depression with regard to positive affect, and animals to encounter depressive disorders. The development in methods that are used for documenting and managing neural activity in the reward system of the brain has led to clear understanding of the neuronal circuits that reveal various symptoms like anhedonia. This enables to a better treatment for depression. Likewise, the basolateral amygdala neuron or their extension into the circuits in central amygdala was detected by optogenetics to reveal the characteristics of anxiety, a frequent symptom of depression, and to regulate conditional fear. The optogenetics technique helps in target-specific identification in a circuit and manipulates the target to fix the dysfunction. The increase prevalence of depression and clinical trials for optogenetics to cure depression is driving the optogenetics market growth.

Restrains:

While optogenetics applications in small animals have yielded new insights into both basic neuroscience as well as diseases of the nervous system, of utmost importance to the eventual translation of these technologies to the clinical realm is their application in nonhuman primates and human tissues. However, several issues prevent direct application of small animal optogenetics techniques to nonhuman primates, including larger brain size, greater importance of safety (i.e., smaller tolerance of vector-related adverse effects), and differing susceptibility to infectious delivery vectors.

Key segments covered:

Segments

Sub-segments

  Sensor Type

  • Calcium (Aequorin, Cameleon, and Other Calcium Sensors)
  • Chloride (Clomeleon)
  • Membrane-gated (Mermaid)
  • Other Sensors

  Application

  • Neuroscience
  • Behavioral Tracking
  • Retinal Disease Treatment
  • Other Applications

  End Users

  • Hospitals
  • Clinics
  • Diagnostic
  • Research
  • Psychiatrist
  • Others

  Region

  • North America
  • Europe
  • Asia-Pacific
  • LAMEA

 

Key benefits of the report:

  • This study presents the analytical depiction of the global Optogenetics industry along with the current trends and future estimations to determine the imminent investment pockets.
  • The report presents information related to key drivers, restraints, and opportunities along with detailed analysis of the global optogenetics market share.
  • The current market is quantitatively analyzed from 2020 to 2027 to highlight the global optogenetics market growth scenario.
  • Porter’s five forces analysis illustrates the potency of buyers & suppliers in the market.
  • The report provides a detailed global optogenetics market analysis based on competitive intensity and how the competition will take shape in coming years.

Questions answered in the Optogenetics Market research report:

  • What are the leading market players active in the optogentics market?
  • What the current trends will influence the market in the next few years?
  • What are the driving factors, restraints, and opportunities in the market?
  • What are the projections for the future that would help in taking further strategic steps?
 
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